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I am honored to have been invited to present the Second Annual Roger Revelle Commemorative Lecture. Although I never had the opportunity to meet or work with Dr. Revelle, his depth and breadth of knowledge and scientific investigations have inspired and challenged oceanographers to interpret the results of their research in the context of systems, rather than as isolated phenomena. It is with this challenge in mind that I will discuss the role of the oceans in human health, and specifically, challenges in realizing the potential for the discovery of new, marine-derived drugs to treat human diseases.